Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype of ALL distinguished by stem-cell-associated and myeloid transcriptional programs.Inactivating alterations of Polycomb repressive complex 2 components are Tacking Strip frequent in human ETP-ALL, but their functional role is largely undefined.We have studied the
Summary: The SARS-CoV-2 papain-like protease (PLpro) is a target for antiviral drug development.It is essential for processing viral polyproteins for replication and functions in host immune evasion by cleaving ubiquitin (Ub) and ubiquitin-like protein (Ubl) conjugates.While highly conserved, SARS-CoV-2 and SARS-CoV PLpro have contrasting Ub/Ubl su
Background: Devising a program to increase physical activity (PA)/exercise behavior in patients with type 2 diabetes mellitus (T2DM) can meet with limited effectiveness in real-world settings because of the variety of barriers to PA/exercise that individuals need to overcome.An alternative approach is to explore whether targeting motivation as a fa
Identifying associations between genetic markers and ALL NATURAL LAUNDRY SODA economic traits has practical benefits for the meat goat industry.To better understand the genomic regions and biological pathways contributing to body conformation traits of meat goats, a genome-wide association study was performed using Dazu black goats (DBGs), a Chines